منابع مشابه
More than a bystander: the contributions of intrinsic skeletal muscle defects in motor neuron diseases
Spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS), and spinal-bulbar muscular atrophy (SBMA) are devastating diseases characterized by the degeneration of motor neurons. Although the molecular causes underlying these diseases differ, recent findings have highlighted the contribution of intrinsic skeletal muscle defects in motor neuron diseases. The use of cell culture and anima...
متن کامل[Mitral regurgitation in patients with systolic heart failure: more than a bystander].
Limitation of exercise capacity is a hallmark of chronic congestive heart failure (HF), varying directly with the severity of the disease. Muscular fatigue and dyspnea on exertion are the most common symptoms of exercise intolerance; however, their origin is still not fully explained. Heart failure is a multifaceted clinical syndrome characterized by the inability of the heart to generate cardi...
متن کاملoct-4: more than a pluripotent marker?
received: 23/sep/2008, accepted: 23/nov/2008oct-4/ pou5f1/ oct-3, a pou domain family protein acts as a crucial transcription factor dur- ing embryonic development. it helps in maintenance of self renewal as well as pluripotential state of embryonic stem (es) cells. its expression starts right from 2 cell stage especially prior to 8 cell stage till the blastocyst stage where it is strongly exp...
متن کاملGalectin-3 in Renal Pathology: More Than Just an Innocent Bystander.
BACKGROUND Galectin-3 is a member of a closely related lectin family, which is detected in several vertebrate epithelial and myeloid cell types. This beta-galactoside-binding soluble protein plays an important role in multiple biological processes. Depending on its location, type of injury or site of damage, the effects by galectin-3 can be various and sometimes contrasting. SUMMARY In this r...
متن کاملMore than a diagnosis.
As educated women, we were bewildered by our medical care, or lack thereof. Following prenatal diagnostics of trisomy 13 or 18, we chose to continue our pregnancies. We understood that our babies would most likely die in utero or soon after birth. To enable ourselves to make informed choices, we sought information from the internet. Here, it was discovered that some babies with these trisomies ...
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ژورنال
عنوان ژورنال: Nature
سال: 2011
ISSN: 0028-0836,1476-4687
DOI: 10.1038/478467a